Medical Blogs

May 7, 2007

World's Largest DNA Scan For Familial Autism Suggests Two New Genetic Links

The first results from a scan of the world's largest collection of DNA samples from families affected by autism point to two new genetic links that may predispose people to the brain disorder. Nature Genetics reports the study's findings in its Feb. 18 online edition.

The five-year study was led by the Autism Genome Project, an international consortium involving scientists from 50 institutions in 19 countries. Founded in 2002 with funding from the nonprofit Autism Speaks and the National Institutes of Health, the group shared DNA samples, data and expertise in a coordinated effort to identify autism-susceptibility genes.

"This degree of collaboration is an unprecedented effort in autism research and demonstrates that a genetic approach is a powerful way to deepen understanding of the disease," said Dr. Daniel Geschwind, director of the Neurogenetics Program at the Jane and Terry Semel Institute for Neuroscience and Human Behavior at UCLA, one of the study's 13 research centers.

"This large-scale study reveals that autism is an extremely diverse condition," Geschwind noted. "Our findings suggest that autism has numerous genetic origins, rather than a single or few major causes."

The consortium used gene-chip technology to search for genetic commonality in autistic individuals from nearly 1,200 families. The scientists also scanned DNA from these families for variations in gene copy numbers -- tiny genomic insertions and deletions that scientists believe might be involved with autism.

"The large number of families in this study permitted us to organize autistic children with similar features of this disorder into smaller groups, where gene linkages may be more easily detected," observed Rita Cantor, professor of human genetics at the David Geffen School of Medicine at UCLA.

Results of the two-pronged approach implicated a previously unidentified region of chromosome 11; and neurexin 1, a member of a gene family believed to play a key role in communication between brain cells. The neurexin finding highlighted a group of brain cells called glutamate neurons and the genes affecting their development and function, suggesting that they play a critical role in autism spectrum disorders.

"We are excited by the results from this large-scale study," said Dr. Stanley Nelson, professor of human genetics at the David Geffen School of Medicine at UCLA, "At the same time, we must greatly increase the number of autistic persons in our genetic analysis in order to fully describe heredity's role in the disease."

"We hope that identifying these genes will provide new insights into what underlies autism," added Geschwind. "We are optimistic that this approach will lead to improved interventions for autistic children and better quality of life for their families."

In 1997, the citizens' group Cure Autism Now (CAN) created a gene bank in order to advance genetic research on autism. UCLA partnered with CAN to add more than 400 families to the gene bank, called the Autism Genetic Resource Exchange, which contributed one-third of the clinical data and samples analyzed by the Autism Genome Project in this study.

The UCLA families who participated had more than one member diagnosed with one of three genetically related diseases: autism, pervasive developmental disorder or Asperger's syndrome. Earlier this month, CAN merged with Autism Speaks to pool their efforts to fund and advance autism research. Autism is a complex brain disorder that strikes in early childhood, often as young as 2 or 3. The condition disrupts a child's ability to communicate and develop social relationships, and is often accompanied by acute behavioral challenges. While the cause remains unknown, scientists suspect the disease is highly hereditary.

Naming autism as a national public health crisis, the Centers for Disease Control and Prevention report that one in 150 American children is diagnosed with an autism spectrum disorder. Affecting four times as many boys as girls, the diagnosis of autism has expanded tenfold in the last decade.

The UCLA Center for Autism Research and Treatment provides diagnosis, family counseling and treatment for patients with autism. Its research focuses on understanding the origins of the disorder's social, communicative and language deficits, and designing and testing new treatments to help autistic children and adults. The center also centralizes autism resources at UCLA and builds partnerships within the autism community.

UCLA is one of eight centers in the NIH-funded Studies to Advance Autism Research and Treatment network, and one of 10 original Collaborative Programs for Excellence in Autism. For more information, see http://www.autism.ucla.edu.

University of California, Los Angeles (UCLA), Health Sciences
924 Westwood Blvd., Ste. 350
Los Angeles, CA 90095
United States
http://healthcare.ucla.edu/

Largest Genomic Search Finds Genes That May Contribute To Autism

An international team of researchers from 19 countries has identified one gene and a previously unidentified region of another chromosome as the location of another gene that may contribute to a child's chances of having autism.

The findings, based on genetic samples from nearly 1,200 families with two or more children who have autism, were published today in Nature Genetics by more than 120 scientists from Europe and North America who make up the Autism Genome Project.

The project was launched in 2002 by scientists at 50 institutions to share data, samples and expertise in an effort to speed up the process of identifying susceptibility genes, those that heighten a child's risk of having the developmental disorder. Seven University of Washington researchers are coauthors of the paper including lead project investigators Gerard Schellenberg and Geraldine Dawson.

The research was funded by Autism Speaks, a nonprofit organization dedicated to increasing awareness of autism and raising money to fund autism research, and the National Institutes of Health.

The consortium scientists utilized statistical power from the largest set of autism-related genetic material yet examined. The researchers found neurexin 1, part of a family of genes that plays a role with the neurotransmitter glutamate, and a still-to-be-pinpointed gene on chromosome 11 to be likely susceptibility genes for autism.

"Neurexin 1 is a highly likely candidate," said Schellenberg, a researcher at the Puget Sound Veterans Affairs Medical Center and a research professor of medicine at the UW. "It is a protein that enables one neuron to contact another neuron. Often you don't have any idea of what a gene does, but in this case we know neurexin 1 is involved at sites where the neurotransmitter glutamate is released. Glutamate is a brain chemical that has been previously implicated in autism. The new finding suggests that the gene is potentially important in autism.

"As for the chromosome 11 location, we think there is another susceptibility gene there and we are actively pursuing it. We are in the neighborhood and have a plan to find it."

Dawson, who directs the UW's Autism Center and is a professor of psychology, said the identification of neurexin 1 is important because glutamate is known to be involved in learning. By identifying this gene it begins to allow researchers "to go from gene to brain to behavior in a way we haven't gone before," she said. "This is a pretty big step and is a precedent showing that autism will require this kind of collaboration to make progress. It is doubtful that any single laboratory could have come up with this kind of finding. This is just the beginning of the fruits from this collaboration."

The Autism Genome Project used two techniques to examine the DNA of the nearly 1,200 families with a history of autism. Researchers used so-called "gene chip" technologies to look for genetic similarities among these family members. In addition, the team scanned the same DNA for what are called copy number variations. These are submicroscopic insertions and deletions of genetic material that scientists believe may be involved with autism and other common diseases.

Schellenberg said copy number variations are fairly common in the human genome and many of them are believed to be benign. "But until you know the function, you don't know what happens when there is an insertion or deletion of this genetic material," he added.

Scientists believe that there may be five or six major genes and perhaps as many as 30 other genes involved in autism. Inheriting more of these genes or certain ones is thought to increase a child's likelihood of being born with autism or a more severe form of the disorder, just as there are genes that heighten a person's chances for inheriting breast cancer or heart disease.

Autism is actually a spectrum of disorders that inhibits a person's ability to communicate and develop social relationships. It is often accompanied by extreme behavior challenges. Autism Spectrum Disorders are diagnosed in one of 166 children in the United States and affect four times as many boys as girls.

"These findings are a piece of the puzzle. As we identify these genes we will be able to screen young children for autism at an early age and begin interventions earlier, which can have a dramatic effect for some children," Dawson said.

A second phase of the Autism Genome Project also was announced today to continue the effort to discover the genes that cause the disorder. This $14.5 million phase is being funded by Autism Speaks, the British Medical Research Council, the Health Research Board of Ireland, Genome Canada and its partners, Canadian Institutes for Health Research, Southwest Autism Research and Resource Center, and the Hilibrand Foundation.

Other UW researchers who contributed to the research are Annette Estes, Jeff Munson, Elena Korvatska, Ellen Wijsman and Chang-En Yu.

University of Washington
Box 351207 Gerberding Hall
Seattle, WA 98195
United States
http://www.washington.edu/

Autism Expert Creates Innovative Intervention Program

Autism is the fastest growing disability in the United States, and public school systems are trying to catch up. One out of every 166 children is diagnosed with autism, making it more common than pediatric cancer, diabetes and AIDS combined.

The Autism Support Services: Education, Research, and Training (ASSERT) program at Utah State University is a state-of-the-art preschool program that uses research-based techniques to address the individual needs of autistic children. USU's pioneer site has opened the doors to a new world for children with autism and is a model training classroom for professionals in the Intermountain region.

Early intervention is key to helping children with autism, and the ASSERT program at Utah State serves as the training grounds for the educators who will make a difference in classrooms. The program offers children a chance to receive help at a young age.

Thomas Higbee, director of USU's Autism Support Services, spent more than 10 years researching and developing cutting-edge ideas that sparked the birth of the ASSERT program. Research has shown that children with autism spectrum disorders (ASD) do not learn readily in typical environments, so Higbee fashioned an atmosphere ideally constructed for ASD treatment.

ASSERT provides consultation services and curriculum to school districts. Higbee and his graduate students frequently visit sites in school districts to provide in-depth training and ensure that students are getting the best instruction possible.

"The hard work has really paid off and we have seen dramatic positive changes in our students," said Higbee.

This individualized educational program has been improving the lives of children with ASD since 2003. What started as a 10-week summer course has become a highly-successful year-round preschool program that continues to revolutionize the way children with autism are educated.

This innovative program serves children three to five years in age. Each child has a personal instructor to work with for 20 hours a week and is given an individualized plan tailored to their needs.

"Intensive behavioral intervention for young children with autism is important because the earlier you work with the children, the bigger positive impact you can have on their progression," Higbee said.

The preschool program also teaches social skills and encourages leisure and play activities with structured peer-play interactions. Functional behavioral assessment and intervention techniques are used to address challenging behaviors.

"Learning doesn't stop at the classroom threshold," Higbee said.

Family training and participation is critical to the success of the program. Families receive periodical professional training and home visits by a team leader twice per month to learn how to continue the program at home.

Fawn Rigby's four-year-old son Zac is a student in the ASSERT program. This education has affected young Zac's life dramatically, and his mother is enthusiastic about ASSERT.

"It's amazing," Rigby said. "ASSERT has given Zac the personal attention he needed. After just a few months, the progress I've seen in him is remarkable."

Higbee has been very satisfied with the outcome of the program and the positive change in the students.

"The life-changing improvements we have expected from our students are happening," Higbee said.

The impact on the students and significant changes can be credited to the intense training and professional caliber of the instructors. Graduate and undergraduate students at USU can apply to work in the program and earn either university credit or compensation while learning how to effectively teach students with ASD.

Higbee said the ASSERT success comes from the rigorous training and satellite program. USU's ASSERT classroom serves as a training site for current and future special education teachers and professionals in related areas such as psychology and speech pathology.

"A big part of our students' success is due to our collaboration with ASSERT," said an aid at a local preschool. "The staff training and continual on-site visits have been vital in keeping our staff qualified to serve our students."

Through ASSERT training, professionals are able to learn behavioral intervention techniques and demonstrate knowledge of behavior principles and how to apply them.

"I have seen a tremendous amount of growth in each child, and I attribute it to the intensive individual programs that are implemented daily," a teacher at a local school said.

ASSERT also provides training to school district personnel on effective educational and behavioral strategies for students with autism. ASSERT continues to help students after preschool and throughout their experience in the public education system.

Dr. Thomas S. Higbee is a national expert on both assessment and intervention strategies for people with autism. He has published 15 research studies and given more than 50 presentations at state and national conferences on the topic. He is Director of the program Autism Support Services: Education, Research, and Training (ASSERT), which he founded in 2003. Over the past 10 years, he has worked with children with developmental disabilities in home-, center-, and school-based programs. He has trained teachers in school districts in California, Utah, Idaho and Wyoming. Dr. Higbee is an assistant professor in the Department of Special Education and Rehabilitation at Utah State University where he has worked since 2002. Before coming to USU, Dr. Higbee served for three years as Senior Clinician at Spectrum Center for Educational and Behavioral Development in Berkeley, Calif., a non-profit agency that operates non-public schools for students with severe disabilities and behavioral disorders.

Utah State University
0500 Old Main Hill
Logan, UT 84322-0500
United States
http://www.usu.edu/ust

Characteristics Of Patients At Increased Risk For Compulsive Gambling Associated With Taking Parkinson's Meds

Patients with Parkinson's disease who are younger when they develop the condition, have a personality trait known as novelty-seeking or whose personal or family history includes alcohol abuse may be more likely to develop pathological gambling as a side effect of medications used to treat their condition, according to a report in the February issue of Archives of Neurology, one of the JAMA/Archives journals.

Behaviors associated with impulse control Including compulsive shopping, hypersexuality, binge eating and pathological gambling have been associated with dopamine agonists, medications used to treat Parkinson's disease. In studies examining the relationship between dopamine agonists and compulsive gambling, the likelihood of gambling problems was unrelated to the medication dosage. This suggests that an underlying trait may interact with the drugs and make an individual more vulnerable to this adverse effect.

Valerie Voon, M.D., National Institute of Neurological Disorders and Stroke, Bethesda, Md., and colleagues compared the characteristics of 21 patients with Parkinson's disease who developed pathological gambling habits after beginning to take dopamine agonists with 42 patients with Parkinson's disease who did not develop compulsive behaviors. The participants, who all visited a clinic in Toronto, Canada, between June 2003 and October 2005, were examined by neurologists and completed assessment scales that measured their levels of impulsivity, substance abuse, mood and anxiety disorders. An additional inventory measured the extent to which the patients displayed novelty-seeking traits, characterized by impulsive and risk-taking behavior and excitement in response to new experiences.

"In keeping with our hypothesis, patients with Parkinson's disease who developed pathological gambling when receiving dopamine agonists had a younger age at Parkinson's disease onset, higher novelty-seeking scores, a personal or immediate family history of alcohol use disorders and impaired planning on an impulsivity scale," the authors write. "A robust association was found with medication-induced mania [a psychiatric disorder involving excessive physical and mental activity and impulsive behavior]." Pathological gambling was also weakly linked to younger age, Parkinson's disease that began in the brain's left hemisphere and a high score on a scale measuring the impulsiveness of behaviors

"Screening for such features and advising those at higher risk may be warranted," the authors conclude.

(Arch Neurol. 2007;64:212-216. Available pre-embargo to the media at http://www.jamamedia.org)

Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

American Medical Association (AMA)
515 N. State St.
Chicago, IL 60610
United States
http://www.ama-assn.org

April 16, 2007

Children Who Believe Intelligence Can Be Developed Perform Better

Research on how junior high school students' beliefs about intelligence affect their math grades found that those who believed that intelligence can be developed performed better than those who believed intelligence is fixed.

The findings come from two studies conducted by researchers at Columbia University and Stanford University, and are published in the journal Child Development.

One study looked at 373 12-year-olds over two years of junior high school. Although all students began the study with equivalent achievement levels in math, students who believed that their intelligence could be developed outperformed those who believed their intelligence was fixed. Furthermore, the researchers found, the gap between these two groups widened over the two-year period.

Researchers concluded that the difference between the two sets of students stems from the fact that students who believed their intelligence could be developed placed a higher premium on learning, believed more in the power of effort, and had more constructive reactions to setbacks in school.

A second study looked at 91 12-year-olds in two groups, both of whom had shown declines in their math grades. One group was taught the expandable theory of intelligence as part of an eight-session workshop on study skills. Another group participated in the same workshop, but did not receive information on the expandable intelligence qualities of the brain. The students who learned about the intelligence theory reversed their decline and showed significantly higher math grades than their peers in the other group, whose grades continued to decline.

"These findings highlight the importance of students' beliefs for their academic progress," said Carol Dweck, one of the researchers and professor of psychology at Stanford University. "They also show how these beliefs can be changed to maximize students' motivation and achievement."

###

Summarized from Child Development, Vol. 78, Issue 1, Implicit Theories of Intelligence Predict Achievement Across an Adolescent Transition: A Longitudinal Study and an Intervention, by Blackwell, LS (Columbia University), and Trzesniewski, KH, and Dweck, CS (Stanford University). Copyright 2007 The Society for Research in Child Development, Inc. All rights reserved.

Contact: Andrea Browning
Society for Research in Child Development

Parents' Genes, Not Parents' Arguing, May Cause Children's Conduct Problems

Children's conduct problems--skipping school, sneaking out of the house, lying to parents, shoplifting, or bullying other children--are a major source of concern for parents and teachers. As a potential cause of these problems, parents' marital conflict has received a lot of research attention. Now a new study finds that parents' fighting may not be to blame but rather that parents who argue a lot may pass on genes for disruptive behavior to their children.

The findings are published in the journal Child Development.

A group of researchers from the University of Virginia and several other universities looked at this question, studying 1,045 twins and their 2,051 children. Some of the parents were identical twins and shared all of their genes and some were fraternal and shared only half of their genes. The study found that parents' fighting is not likely a cause of children's conduct problems. On the other hand, parents' genes influenced how often they argued with their spouses and these same genes, when passed to their children, caused more conduct problems.

"This study suggests that marital conflict is not a major culprit, but genes are," said K. Paige Harden, the lead researcher and professor of psychology at the University of Virginia. "Our findings have potential implications for treating conduct problems: Focusing on a child's parents, as is common in family therapy, may not be as effective as focusing on the child."

###

The study was supported, in part, by grants from the National Institute on Alcohol Abuse and Alcoholism and the National Alliance for Research on Schizophrenia and Depression.

Summarized from Child Development, Vol. 78, Issue 1, Marital Conflict and Conduct Problems in Children-of-Twins, by Harden, KP, Turkheimer, E, and Emery, RE (University of Virginia), D'Onofrio, BM (Indiana University), Slutske, WS (University of Missouri), Heath, AC (Washington University, St. Louis), and Martin, NG (Queensland Institute of Medical Research). Copyright 2007 The Society for Research in Child Development, Inc. All rights reserved.

###

Contact: Andrea Browning
Society for Research in Child Development

Study Questions 'One Size Fits All' Approach When Measuring Income's Effect On School Readiness

A lot of research has examined the effect of a family's income on children's readiness to start school. A new study suggests that adopting a "one size fits all" approach - that is, measuring material hardship, parenting, and school readiness in the same way for white, black, and Hispanic children - may obscure the toll that lower income takes on ethnic minority children as well as the strengths that some families show in coping with poverty-related disadvantages.

These findings come from researchers at the University of Chicago, the University of Michigan, and New York University, and are published in the journal Child Development. The research was supported by a grant from the National Institute of Child Health and Human Development.

The study looked at children enrolled in the Early Childhood Longitudinal Study, Kindergarten Class of 1998-99, a nationally representative study of more than 21,000 kindergarteners. The researchers found that a common yardstick of school readiness has been used in measuring pre-academic and socio-emotional skills among ethnic minority and white children. But they found that the same yardstick in measuring parenting and stressors related to poverty yields different answers, depending on families' race and ethnic identity. This suggests that researchers think twice before assuming that "one size fits all" in such studies.

Despite these findings, however, when the researchers looked at models of how low income might affect parenting and children's readiness for school, they found similarities across racial and ethnic groups. Regardless of race and ethnicity, lower family income was associated with increased hardship, higher levels of stress, less positive parenting behavior, and more problematic behavior in kindergartners.

"We can conclude, on the one hand, that low income affects all families similarly, regardless of the sociocultural contexts in which families live," says C. Cybele Raver, associate professor in the Harris Graduate School of Public Policy Studies at the University of Chicago. "On the other hand, the differences we found in how certain aspects of hardship and parenting are measured suggest that the sociocultural context of minority families alters the meanings of these constructs among families."

###

Summarized from Child Development, Vol. 78, Issue 1, Testing Equivalence of Mediating Models of Income, Parenting, and School Readiness for White, Black, and Hispanic Children in a National Sample, by Raver, CC (University of Chicago), Gershoff, ET (University of Michigan), and Aber, JL (New York University). Copyright 2007 The Society for Research in Child Development, Inc. All rights reserved.

###

Contact: Andrea Browning
Society for Research in Child Development

Conscience, Religion Alter How Doctors Tell Patients About Options

Many physicians feel no obligation to tell patients about legal but morally controversial medical treatments or to refer patients to doctors who do not object to those treatments, report researchers from the University of Chicago in the New England Journal of Medicine.

The medical profession appears to be divided, the researchers note, not just in its attitudes about providing controversial practices such as terminal sedation, abortion or birth control for teens, but also in its judgments about what doctors should do when patients request a legal procedure to which their doctor objects.

The study found that although 86 percent of doctors did feel obliged to present all options in such cases, only 71 percent said they would feel obligated to refer the patient to a doctor who did not object to the requested procedure, and 63 percent believed it is ethically permissible for a doctor to describe his or her objection to the patient.

This affects millions of people, the authors note. "If physicians' ideas translate into their practices, then 14% of patients - more than 40 million Americans - may be cared for by physicians who do not believe they are obligated to disclose information about medically available treatments they consider objectionable. In addition, 29% of patients - or nearly 100 million Americans - may be cared for by physicians who do not believe they have an obligation to refer the patient to another provider for such treatments."

"Our survey data point to a basic dilemma facing patients and physicians in our plural democracy," said study author Farr Curlin, M.D., assistant professor of medicine and a member of the MacLean Center for Clinical Medical Ethics at the University of Chicago. "Because patients and physicians come from many different moral traditions, religious and secular, they will sometimes disagree about whether a particular medical intervention is morally permissible."

The researchers mailed a 12-page questionnaire to 2,000 physicians from all specialties; 1,144 (63 percent) responded.

They asked physicians if they had objections to three controversial clinical practices. Only 17 percent objected to terminal sedation (sedating dying patients to the point of unconsciousness), but 42 percent objected to prescription of birth control to teenagers without parental consent, and 52 percent objected to abortion for failed contraception.

They also asked physicians about their sense of obligation when patients request such procedures. Should physicians "present all possible options?" May a physician who objects to a procedure "plainly describe why?" If the physician objects, does he or she "have an obligation to refer the patient to someone who does not object?"

The study found that the answers to those questions were highly associated with doctors' sex, religious characteristics and whether or not they personally object to one or more controversial clinical practices. Male physicians, those who were more religious (particularly Catholics and Protestants) and those who personally objected to controversial clinical practices were all more likely to believe that doctors may describe their objections to patients. They also were less likely to believe that physicians must present all options or refer patients to someone who does not object to the requested procedures.

In the past, researchers have consistently found that religious physicians are more likely to personally object to a range of different controversial clinical practices, Curlin said. "This study suggests that those most likely to be asked to act against their consciences are the ones most likely to say physicians should not have to do so."

While 86 percent felt obliged to present all possible options, six percent were undecided and another eight percent felt no such responsibility. Sixty-three percent felt it was ethical to "plainly describe" why they objected to a requested procedure. Eighteen percent felt no obligation to refer a patient to another doctor who did not object, and another 11 percent were undecided about their responsibility to refer.

Such situations raise basic philosophical questions, said co-author John Lantos, M.D., professor of pediatrics and medicine and associate director of the MacLean Center. "Is there room within the profession for radically different approaches to care based on moral or religious opinions? Should doctors leave their personal religious beliefs at the door, or are those beliefs such a central element of personal identity that the very notion of leaving them at the door is incomprehensible?"

When the authors mentioned their results to colleagues they drew widely varied reactions. A few physicians thought patients had no right to expect morally objectionable treatments, Lantos said. Others thought that doctors who would deny beneficial treatments had no business practicing medicine. But most took to the middle ground. "They felt that doctors had the right to follow their conscience," Lantos said, "and patients had a right to legal, medically approved treatment."

This middle ground places a lot of the burden onto patients, the authors admit. "Patients should know that physicians are divided on this issue," Curlin said. They may want to "talk to their physicians up front to find out where they stand. If they anticipate areas of moral disagreement, they should try to negotiate acceptable accommodations before a crisis develops."

###

The Greenwall Foundation, the National Center for Complementary and Alternative Medicine and the Robert Wood Johnson Clinical Scholars Program funded the study. Additional authors were Ryan Lawrence and Marshall Chin of the University of Chicago.

Contact: John Easton
University of Chicago Medical Center

Extra Cortisol Protects Women's Mood Under Stress

German researchers have found additional evidence that the stress hormone cortisol can have positive effects in certain situations. Although chronic stress, which brings long-term elevations of cortisol in the bloodstream, can weaken the immune system and induce depression, this new study adds to mounting evidence that cortisol given near in time to a physical or psychological stress may lessen the stressor's emotional impact. Psychologists are especially interested in what this means for preventing and treating post-traumatic stress disorder. The findings appear in the February issue of Behavioral Neuroscience, which is published by the American Psychological Association (APA).

Psychologists Serkan Het, MSc, and Oliver Wolf, PhD, of the University of Bielefeld, enlisted 44 healthy women for a double-blind study, in which neither researchers or participants knew the condition to which the women were assigned. One hour before a psychosocial stress test, participants were given either a 30 mg. dose of oral cortisol or a placebo. That 30 mg. dose is considered high, translating to a severe stressor. Experimenters tracked participant mood through self report, and measured their cortisol levels with a simple swab check of their saliva, before and after the psychosocial stress test.

Participants were asked to give five-minute oral presentations as if interviewing for their dream job, focusing on their personal strengths and weaknesses. For the next five minutes, they had to count backwards by 17s from a very high number; every time they made a mistake, they had to start over. During both tasks, participants faced a "committee" of one man and one woman, both of whom acted cold and reserved without actually being unfriendly or rude. To heighten discomfort over being evaluated, participants spoke into microphones and knew they were being videotaped.

Het and Wolf measured mood five times using two self-report questionnaires, 15 and 45 minutes participants arrived at the lab, and 1, 45, and 60 minutes after the stress test. Afterwards, the cortisol-treated women developed, on average, less negative mood states as a result of the stress-producing activity when compared with placebo-treated women. The high dose of cortisol seems to have worked as a buffer.

Wolf says that whereas chronically elevated cortisol levels can be damaging to both mood and immunity, a short spike in cortisol levels may be protective. He comments, "The difference between acute cortisol elevations and chronic cortisol hyperactivity appears to be important."

Prior research has suggested that low-dose treatment with cortisol can offer relief from the core symptoms of post-traumatic stress disorder. In addition, in patients with social phobia exposed to a social stress situation, pre-treatment with cortisol has reduced anxiety. This new study in healthy participants adds to the growing body of evidence that cortisol may be a useful clinical tool. Says Wolf, "Our study suggests that when it comes to the negative effects of stress on the emotions, an anticipatory rise in cortisol levels prior to a stressor might help someone to cope with the stressor more efficiently. This might have implications for treating and preventing post-traumatic stress and other anxiety disorders."

Article: "Mood Changes in Response to Psychosocial Stress in Healthy Young Women: Effects of Pretreatment with Cortisol," Serkan Het, MSc, and Oliver T. Wolf, PhD, University of Bielefeld; Behavioral Neuroscience, Vol. 121, No. 1.

The American Psychological Association (APA), in Washington, DC, is the largest scientific and professional organization representing psychology in the United States and is the world's largest association of psychologists. APA's membership includes more than 150,000 researchers, educators, clinicians, consultants and students. Through its divisions in 54 subfields of psychology and affiliations with 60 state, territorial and Canadian provincial associations, APA works to advance psychology as a science, as a profession and as a means of promoting human welfare.

American Psychological Association (APA)
750 First St., NE
Washington, DC 20002-4242
United States
http://www.apa.org

Children's Perceptions Of Their Parents' Antisocial Behavior May Lead Them To Be Antisocial

Children who grow up in antisocial families are more likely to be antisocial themselves. Much of the research into why this is so has focused on parents' behavior. A new study finds that the way children perceive their parents' behavior provides clues as to why children of antisocial parents may grow up to be antisocial.

The study, conducted by researchers at the University of California, Davis, and Virginia Polytechnic Institute and State University, appears in the journal Child Development. The research was funded in part by the National Institute of Child Health and Human Development, the National Institute on Drug Abuse, and the National Institute of Mental Health.

In an effort to determine how antisocial behavior in one generation is transmitted to the next, researchers looked at 430 adolescents and their biological parents across the children's high school years. Specifically, the study examined the adolescents' level of antisocial behavior, the level of such behavior in parents, and the teens' general perceptions of their parents' behavior. Antisocial behavior was defined in terms of substance use, recklessness and breaking laws, arguments and conflicts with others, and lying. The study examined if the effect of parents' antisocial behavior on the teens' antisocial behavior could be explained by the teens' perceptions of their parents as antisocial, as well as by disrupted parenting practices, such as poor monitoring, hostility, and harsh and inconsistent discipline.

The researchers concluded that the children learned antisocial behavior by observing and interpreting their parents' antisocial behavior. Parents' behavior provides children with a model for their own behavior, and children's perception that a parent is antisocial may be a key component in choosing and validating their own behaviors, giving children permission to engage in this type of behavior. For the teenagers in this study, the recognition of antisocial behavior in their parents played an important role in increasing their risk for similar conduct; in fact, it played more of a role than the teens' assessment of their parents' parenting abilities.

Furthermore, the findings were the same for the effect of both fathers' and mothers' antisocial behavior and parenting on the development and growth of boys' and girls' antisocial behavior. A notable finding was that the strongest influence on a child's antisocial behavior in the 12th grade was that child's own level of behavior in 9th grade. This indicates that there is stability in antisocial behavior through adolescence, and that the processes reported in this study are well under way by the 9th grade.

"These findings suggest that focusing on how children perceive mom and dad's behavior and the origin of these perceptions could facilitate family-centered interventions designed to reduce the risk for problem behavior," according to Shannon J. Dogan, the study's lead author and a research assistant at the University of California, Davis. "Further, identifying antisocial parents would assist in early identification of at-risk families. Interventions that reduce parental antisocial behavior and improve parenting practices should also reduce levels of problem behavior among teens."

###

Summarized from Child Development, Vol. 78, Issue 1, Cognitive and Parenting Pathways in the Transmission of Antisocial Behavior from Parents to Adolescents, by Dogan, SJ, and Conger, RD (University of California, Davis), Kim, KJ (Virginia Polytechnic Institute and State University), and Masyn, KE (University of California, Davis). Copyright 2007 The Society for Research in Child Development, Inc. All rights reserved.

Contact: Andrea Browning
Society for Research in Child Development